Journal
CURRENT NEUROPHARMACOLOGY
Volume 14, Issue 4, Pages 307-313Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570159X14666151208114232
Keywords
Alzheimer's disease; antipsychotic; behavioral and psychological symptoms of dementia; dementia; drug; psychiatric symptoms
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Funding
- National Natural Science Foundation of China [8141038009]
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Dementia, which can be induced by diverse factors, is a clinical syndrome characterized by the decline of cognitive function. Behavioral and psychological symptoms of dementia (BPSD) include depression, agitation, and aggression. Dementia causes a heavy burden on patients and their caregivers. Patients with BPSD should be assessed comprehensively by practitioners and offered appropriate non-pharmacologic and pharmacologic therapy. Non-pharmacologic therapy has been recommended as the basal treatment for BPSD; however, pharmacologic therapy is required under many situations. Medications, including antipsychotic agents, antidepressants, sedative and hypnotic agents, mood stabilizers, cholinesterase inhibitors, and amantadine, are extensively used in clinical practice. We have reviewed the progression of pharmacologic therapy for BPSD.
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