Biological Characteristics and Roles of Noncoding RNAs in Milk-Derived Extracellular Vesicles

Extracellular vesicles (EVs) have diverse roles in the transport of proteins, lipids, and nucleic acids between cells, and they serve as mediators of intercellular communication. Noncoding RNAs (ncRNAs) that are present in EVs, including microRNAs, long noncoding RNAs, a nd circular RNAs, have been found to participate in complex networks of interactions and regulate a wide variety of genes in animals. Milk is an important source of nutrition for humans and other mammals. Evidence suggests that milk-derived EVs contain abundant ncRNAs, which are stable and can be transported to the offspring and other consumers. Current data suggest a strong link between milk EV ncRNAs and many biological processes, and these ncRNAs have been drawing increasing attention and might play an epigenetic regulatory role in recipients, though further research is still necessary to understand their precise roles. The present review introduces basic information about milk EV ncRNAs, summarizes their expression profiles, biological characteristics, and functions based on current knowledge, and discusses their biological roles, indeterminate issues, and perspectives. Our goal is to provide a deeper understanding of the physiological effects of milk EV ncRNAs on offspring and to provide a reference for future research in this field.

Automated summary

Extracellular vesicles (EVs) containing noncoding RNAs (ncRNAs), such as microRNAs, long noncoding RNAs, and circular RNAs, are crucial for intercellular communication. Milk-derived EV ncRNAs have been shown to play significant roles in biological processes and may have epigenetic regulatory effects in recipients. Further research is needed to fully understand the precise functions of milk EV ncRNAs.