Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202001183
Keywords
cyclodextrin; gene therapy; nucleic acid delivery; organic; inorganic nanohybrid; supramolecular self-assembly
Funding
- National Natural Science Foundation of China [51733001, 21875014, 51829301]
- Beijing Outstanding Young Scientist Program [BJJWZYJH01201910010024]
- Fundamental Research Funds for the Central Universities [XK1802-2, ZY2027, ZY2028]
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This review focuses on the construction strategies and biomedical applications of cyclodextrin (CD)-based nucleic acid delivery systems. It covers the synthesis and properties of simple CD-grafted polycations, CD-related supramolecular assemblies, and CD-based organic/inorganic nanohybrids. The review aims to inspire the delicate design of CD-based nucleic acid delivery systems for potential clinical applications.
Nowadays, nucleic acid therapy has become a promising way for the treatment of various malignant diseases. Cyclodextrin (CD)-based nucleic acid delivery systems have attracted widespread attention due to the favorable chemical structures and excellent biological properties of CD. Recently, a variety of CD-based nucleic acid delivery systems has been designed according to the different functions of CD for flexible gene therapies. In this review, the construction strategies and biomedical applications of CD-based nucleic acid delivery systems are mainly focused on. The review begins with an introduction to the synthesis and properties of simple CD-grafted polycations. Thereafter, CD-related supramolecular assemblies based on different guest components are discussed in detail. Finally, different CD-based organic/inorganic nanohybrids and their relevant functions are demonstrated. It is hoped that this brief review will motivate the delicate design of CD-based nucleic acid delivery systems for potential clinical applications.
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