Brain Glioma Localization Diagnosis Based on Magnetic Resonance Imaging

BACKGROUND: We used dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) technology and its perfusion parameters to diagnose central glioma high-grade glioma (HGG), primary central nervous system glioma low-grade glioma (LGG), brain metastases, and meningioma and make differential diagnoses. METHODS: Forty-one cases of brain tumors (8 cases of LGG, 17 cases of HGG, 5 cases of primary central nervous system lymphoma = PCNSL], 6 cases of brain metastases, and 5 cases of meningiomas) were subjected to routine and DCE-MRI scans. The DCE-MRI quantitative parameters of the tumor parenchymal area and peripheral enema area of each tumor were measured and recorded as t-Ktrans value, t-Ve value, t-Vp value, t-Kep value and p-Ktrans value, p-Ve value, p-Vp value, and p-Kep value. RESULTS: Compared with other tumor types, LGG showed lower t-Ktrans value (P < 0.01, sensitivity = 89%, specificity = 99%) and low t-Ve value (P < 0.01, sensitivity = 94%, specificity = 100%); PCNSL showed a high tVe value (P < 0.01, sensitivity = 100%, specificity = 88%), but other perfusion parameters overlap more obviously with other tumors. Compared with LGG, the difference between t-Ktrans value, t-Ve value, and t-Kep value is statistically significant. Among them, t-Ktrans value distinguishes the highest sensitivity and specificity (when t-Ktrans value = when 0.154 is the cutoff value, the area under the curve is 1.000, P = 0.000, specificity = 100%, sensitivity = 94.1%); compared with PCNSL, the difference of t-Ve value between HGG and PCNSL is statistically significant, t-Ve of PCNSL. The value is slightly higher, and its specificity and sensitivity are not high. CONCLUSIONS: DCE-MRI can distinguish HGG and LGG more accurately, of which t-Ktrans value has higher specificity and sensitivity, although the difference of t-Ve value between PCNSL and HGG is statistically significant but the sensitivity and specificity are not high; the p-Ktrans value and p-Kep value of metastatic tumors are lower than HGG and have higher specificity, but meningiomas and HGG and PCNSL, meningiomas and metastases are not accurate identification.

Automated summary

This study utilized DCE-MRI technology and its perfusion parameters to diagnose and differentially diagnose brain tumors, showing that DCE-MRI can accurately distinguish between HGG and LGG, with t-Ktrans value demonstrating higher specificity and sensitivity.