4.6 Review

The Effects of Vitamin B in Depression

Journal

CURRENT MEDICINAL CHEMISTRY
Volume 23, Issue 38, Pages 4317-4337

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867323666160920110810

Keywords

Depression; vitamin B; vitamin B6; vitamin B12; vitamin B complex

Funding

  1. Victoria University Summer Scholarship
  2. College of Health and Biomedicine
  3. Rebecca L Cooper Medical Research Foundation
  4. Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Australia

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Vitamins are dietary components which are necessary for life. They play a major role in health and their deficiency may be linked to symptoms of psychiatric disorders. B vitamins are required for proper functioning of the methylation cycle, monoamine oxidase production, DNA synthesis and the repair and maintenance of phospholipids. Vitamin B deficiency could influence memory function, cognitive impairment and dementia. In particular, vitamins B1, B3, B6, B9 and B12 are essential for neuronal function and deficiencies have been linked to depression. We discuss the causes of depression and the neurochemical pathways in depression. In particular, we provide evidence that vitamin B contributes to the complexity of depressive symptoms.

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