Journal
NUTRIENTS
Volume 12, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nu12113252
Keywords
bilberry; anthocyanins; NAFLD; dyslipidemia; gut microbiome
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [20K05928]
- Scholar Research of Kagoshima University Fund [70030117]
- Grants-in-Aid for Scientific Research [20K05928] Funding Source: KAKEN
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Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome closely linked to dyslipidemia and gut microbiome dysbiosis. Bilberry anthocyanins (BA) have been reported to have preventive effects against metabolic syndrome. This study aimed to investigate the protective effects and mechanisms of BA in a Western diet (WD)-induced mouse model. The results revealed that supplementation with BA attenuated the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-c), fat content in liver, 2-thiobarbituric acid reactive substances (TBARS) and alpha-smooth muscle actin (alpha-SMA) caused by WD. Furthermore, gut microbiota characterized by 16S rRNA sequencing revealed that BA reduced remarkably the ratio of Firmicutes/Bacteroidetes (F/B) and modified gut microbiome. In particular, BA increased the relative abundance of g_Akkermansia and g_Parabacteroides. Taken together, our data demonstrated that BA might ameliorate WD-induced NAFLD by attenuating dyslipidemia and gut microbiome dysbiosis.
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