Journal
NUTRIENTS
Volume 12, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/nu12092604
Keywords
anorexia nervosa; eating disorders; starvation; hyperactivity; neuropeptides; microbiome– gut– brain axis
Categories
Funding
- Priority Research Area BioS under the program Excellence Initiative-Research University at the Jagiellonian University in Krakow
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Anorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological aspects involving central and peripheral neurohormonal pathways, endocrine function, as well as the microbiome-gut-brain axis. It emerged from the unique complexity of constantly accumulating new discoveries, which hamper the ability to look at the disease in a more comprehensive way. The emphasis is placed on the mechanisms underlying the main symptoms and potential new directions that require further investigation in clinical settings.
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