Journal
CURRENT MEDICINAL CHEMISTRY
Volume 23, Issue 25, Pages 2826-2835Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867323666160411142909
Keywords
Niacin; Vitamin B3; Hyperlipemia; Triglyceride-rich lipoproteins; Postprandial state; Cardiovascular disease
Funding
- Spanish Ministry of Science and Innovation, MICINN [AGL2011-29008]
- FPI fellowship of MICINN [BES-2012-056104]
- V Own Research Plan (University of Seville)
- Spanish Research Council (CSIC)/Juan de la Cierva
Ask authors/readers for more resources
The well-known changes in modern lifestyle habits including over nutrition and physical inactivity have led to striking adverse effects on public health (e.g., obesity, diabetes, and metabolic syndrome) over recent decades. One noticeable consequence is exaggerated and prolonged state of postprandial hyperlipemia due to the ingestion of multiple fat-enriched meals during the course of a day. Postprandial (non-fasting) hyperlipemia is characterized by increased blood levels of exogenous triglycerides (TG) in the form of apolipoprotein (apo) B48-containing TG-rich lipoproteins (TRL), which have a causal role in the pathogenesis and progression of cardiovascular disease (CVD). The cardiovascular benefits of lifestyle modification (healthy diet and exercise) and conventional lipid-lowering therapies (e.g., statins, fibrates, and niacin) could involve their favourable effects on postprandial metabolism. Pharmacologically, niacin has been used as an athero-protective drug for five decades. Studies have since shown that niacin may decrease fasting levels of plasma very-low-density lipoproteins (VLDL), low-density lipoprotein cholesterol (LDL-C), and lipoprotein [a] (Lp[a]), while may increase high-density lipoprotein cholesterol (HDL-C). Herein, the purpose of this review was to provide an update on effects and mechanisms related to the pharmacological actions of niacin on acute hyperlipemia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available