Journal
NUCLEIC ACID THERAPEUTICS
Volume 30, Issue 6, Pages 414-421Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/nat.2020.0899
Keywords
aptamers; chemical modifications; G-quadruplex; prion protein
Funding
- Future in Research grant from the Italian Ministry of University and Research (MIUR) [RBFR13XFXR]
- JSPS KAKENHI [18K19397, 20H03192, 16K07269]
- Grants-in-Aid for Scientific Research [20H03192, 18K19397, 16K07269] Funding Source: KAKEN
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Nucleic acid aptamers are innovative and promising candidates to block the hallmark event in the prion diseases, that is the conversion of prion protein (PrP) into an abnormal form; however, they need chemical modifications for effective therapeutic activity. This communication reports on the development and biophysical characterization of a small library of chemically modified G-quadruplex-forming aptamers targeting the cellular PrP and the evaluation of their anti-prion activity. The results show the possibility of enhancing anti-prion aptamer properties through straightforward modifications.
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