Journal
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
Volume 20, Issue 3, Pages 188-197Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1534734620963561
Keywords
diabetic foot ulcers; advanced treatments; standard of care; wound healing
Categories
Ask authors/readers for more resources
Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes mellitus, with treatment options including both standard care such as pressure off-loading and advanced therapies like growth factors and stem cells.
Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes mellitus that is associated with increased morbidity and mortality, as well as substantial economic burden for the health care system. The standard of care for DFUs includes pressure off-loading, sharp debridement, and wound moisture balance, along with infection control and management of peripheral arterial disease. A variety of advanced modalities that target distinct pathophysiological aspects of impaired wound healing in diabetes are being studied as possible adjunct therapies for difficult to heal ulcers. These modalities include growth factors, stem cells, cultured fibroblasts and keratinocytes, bioengineered skin substitutes, acellular bioproducts, human amniotic membranes, oxygen therapy, negative pressure wound therapy, and energy therapies. Additionally, the use of advanced biomaterials and gene delivery systems is being investigated as a method of effective delivery of substances to the wound bed. In the present narrative review, we outline the latest advances in the nonpharmacological management of DFUs and summarize the efficacy of various standard and advanced treatment modalities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available