Journal
CELL ADHESION & MIGRATION
Volume 14, Issue 1, Pages 227-241Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2020.1827665
Keywords
MicroRNA-203; CAV1; PI3K; AKT signaling; renal cell carcinoma; proliferation; apoptosis; epithelial-mesenchymal transformation; migration; invasion
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The present study aimed to evaluate the underlying mechanism of microRNA-203 (miR-203) in renal cell carcinoma (RCC) involving the PI3K/AKT signaling pathway. The results revealed downregulated miR-203 and upregulated CAV1 in RCC tissues. Upregulated miR-203 and downregulated CAV1 increased E-cadherin expression and cell apoptosis, decreased beta-catenin and N-cadherin expression and cell proliferation, migration and invasion, and blocked cell cycle entry. CAV1, a target gene of miR-203, decreased by up-regulated miR-203, and silencing CAV1 led to the inactivation of PI3K/AKT signaling pathway. In conclusion, our findings suggested that miR-203-mediated direct suppression of CAV1 inhibits EMT of RCC cells via inactivation of the PI3K/AKT signaling pathway.
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