Journal
BIOMEDICAL OPTICS EXPRESS
Volume 11, Issue 10, Pages 5717-5727Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.400686
Keywords
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Funding
- H2020 European Research Council [681514, 741149]
- ERCH2020 Marie Sklodowska-Curie Actions [DARWIN, 750420]
- Engineering and Physical Sciences Research Council [NS/A000050/1]
- European Research Council (ERC) [681514] Funding Source: European Research Council (ERC)
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We present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. From the measurement of a transmission matrix during a prior calibration step, a focused spot is produced and raster-scanned over a sample at the distal tip of the fiber by use of a fast spatial light modulator. An ultra-sensitive fiber-optic ultrasound sensor for photoacoustic detection placed next to the fiber is combined with a photodetector to obtain both fluorescence and photoacoustic images with a distal imaging tip no larger than 250 mu m. The high signal-to-noise ratio provided by wavefront shaping based focusing and the ultra-sensitive ultrasound sensor enables imaging with a single laser shot per pixel, demonstrating fast two-dimensional hybrid in vitro imaging of red blood cells and fluorescent beads. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License.
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