4.6 Article

Qualitative disorder measurements from backscattering spectra through an optical fiber

Journal

BIOMEDICAL OPTICS EXPRESS
Volume 11, Issue 10, Pages 6038-6048

Publisher

OPTICAL SOC AMER
DOI: 10.1364/BOE.396013

Keywords

-

Funding

  1. Horizon 2020 Framework Programme [801347-SENSITIVE]
  2. Ministerio de Economia y Competitividad [FIS2016-77892-R]
  3. Conselleria d'Educacio, Investigacio, Cultura i Esport [APOSTD/2018/A/084]
  4. Comunidad de Madrid [S2017/BMD-3867 RENIM-CM]
  5. Ministerio de Ciencia, Innovacion y Universidades [SEV-2015-0505]

Ask authors/readers for more resources

In the processes related to the development of cancer, there are different genetic and epigenetic events involved that result in structural changes of the affected cells. In the early stages of the disease, these changes occur at the nanoscale, remaining undetectable by conventional light microscopy, due to diffraction-limited resolution (similar to 250 - 550 nm). In this sense, a technique termed partial wave spectroscopy (PWS) allows the detection of these nanostructural changes by measuring a statistical parameter called disorder strength (L-d). PWS uses a combination of a tunable filter and a camera to acquire the backscattering spectra for each pixel on the image. In this paper, we study and validate the possibility of obtaining a qualitative measurement of the disorder using the spectrum of the averaged spatial information. Instead of using spatial information and measuring sequentially spectral ranges, we measure the backscattered signal gathered by an optical fiber by means of a spectrograph. This will allow this method to be applied in systems where it is not possible to acquire a complete high resolution image for many spectral bands, while significantly enhancing speed. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available