Journal
BIOMEDICAL OPTICS EXPRESS
Volume 11, Issue 9, Pages 5306-5320Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.399334
Keywords
-
Funding
- National Eye Institute [P30 EY001792, R01 EY023522, R01 EY029673, R01 EY030101, R01 EY030842]
- University of Illinois at Chicago (Richard and Loan Hill Endowment)
- Research to Prevent Blindness
Ask authors/readers for more resources
Stimulus-evoked intrinsic optical signal (IOS), which occurs almost immediately after the onset of retinal stimulus has been observed in retinal photoreceptors, promises to be a unique biomarker for objective optoretinography (ORG) of photoreceptor function. We report here the first-time in vivo ORG detection of photoreceptor dysfunction due to retinal degeneration. A custom-designed optical coherence tomography (OCT) was employed for longitudinal ORG monitoring of photoreceptor-IOS distortions in retinal degeneration mice. Depth-resolved OCT analysis confirmed the outer segment (OS) as the physical source of the photoreceptor-IOS. Comparative ERG measurement verified the phototransduction activation as the physiological correlator of the photoreceptor-IOS. Histological examination revealed disorganized OS discs, i.e. the pathological origin of the photoreceptor-IOS distortion. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available