Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 13, Issue 12, Pages 8613-8625Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2020.09.047
Keywords
Core-shell Cu2O@CeO2; Paracetamol; P-nitrophenol; P-anomiphenol; Selective conversion
Categories
Funding
- National Natural Science Foundation of China [21777078, 22062016]
- Major Project of Inner Mongolia Natural Science Foundation [2020ZD02]
- Project of Research and Development of the Applied Technology for Inner Mongolia of China [2020SGG0065]
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The selectivity and reactivity to converse series nitroaromatic into aminobenzenes are especially significant, which play a vital role in synthesizing required drugs or other fine chemicals. Herein, p-nitrophenol (p-NP) has been completely conversed into p-anomiphenol (p-AP) with a high activity factor k (0.033 s(-1).mg(-1)) and reusability by core-shell Cu2O@CeO2 catalyst. N-acetyl-para-aminophenol (paracetamal, APAP) as a model drug was further synthesized via a flow route proceeded in two steps including p-NP reduction and subsequently p-AP acylation with self-constructing device. The yield of the paracetamal is up to 85% with a highly purity. The mechanism investigation justifies the rich-electron centers and cation defects generated from the redox coupled Cu+-> Cu-0 with Ce3+-> Ce4+ will steer selective conversion of p-NP to p-AP, a rate-determining step in the production of APAP. The present results could visualize a highly selective catalyst and a new synthesis route for pharmaceuticals such as paracetamal by using nitroaromatic compounds as the raw materials with environment-friendly, low-cost, easy-manipulation, high-efficiency and high purity. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
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