Related references
Note: Only part of the references are listed.Supply and demand-heme synthesis, salvage and utilization by Apicomplexa
Joachim Kloehn et al.
FEBS JOURNAL (2021)
Identification of a Master Regulator of Differentiation in Toxoplasma
Benjamin S. Waldman et al.
CELL (2020)
Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism
Aarti Krishnan et al.
CELL HOST & MICROBE (2020)
Characterization of the apicoplast-localized enzyme TgUroD in Toxoplasma gondii reveals a key role of the apicoplast in heme biosynthesis
Edwin T. Tjhin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites
Jakob Birnbaum et al.
SCIENCE (2020)
The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation
Ryan C. Henrici et al.
MBIO (2020)
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13
Nina F. Gnädig et al.
PLoS Pathogens (2020)
CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing
Kornel Labun et al.
NUCLEIC ACIDS RESEARCH (2019)
5-Aminolevulinate synthase catalysis: The catcher in heme biosynthesis
Bosko M. Stojanovski et al.
MOLECULAR GENETICS AND METABOLISM (2019)
Optimizing Systems for Cas9 Expression in Toxoplasma gondii
Benedikt M. Markus et al.
MSPHERE (2019)
Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance
Tuo Yang et al.
CELL REPORTS (2019)
Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii
Alex Hunt et al.
ELIFE (2019)
Single-pot, solid-phase-enhanced sample preparation for proteomics experiments
Christopher S. Hughes et al.
NATURE PROTOCOLS (2019)
The PRIDE database and related tools and resources in 2019: improving support for quantification data
Yasset Perez-Riverol et al.
NUCLEIC ACIDS RESEARCH (2019)
Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii
Alex Rosenberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core
Lukas Zimmermann et al.
JOURNAL OF MOLECULAR BIOLOGY (2018)
CRISPR-Cas9-based genome-wide screening of Toxoplasma gondii
Saima M. Sidik et al.
NATURE PROTOCOLS (2018)
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Annie N. Cowell et al.
SCIENCE (2018)
Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites
Frances Rocamora et al.
PLOS PATHOGENS (2018)
Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro
Joshua B. Radke et al.
ACS INFECTIOUS DISEASES (2018)
High-content imaging assay to evaluate Toxoplasma gondii infection and proliferation: A multiparametric assay to screen new compounds
Bastien Touquet et al.
PLOS ONE (2018)
Heme-dependent Inactivation of 5-Aminolevulinate Synthase from Caulobacter crescentus
Hiroko Ikushiro et al.
SCIENTIFIC REPORTS (2018)
Identification of cryptic subunits from an apicomplexan ATP synthase
Diego Huet et al.
ELIFE (2018)
Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase
Azadeh Seidi et al.
ELIFE (2018)
Dihydroartemisinin-Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance
Laura E. Heller et al.
BIOCHEMISTRY (2018)
A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation
Kimberly F. Breglio et al.
MALARIA JOURNAL (2018)
Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility
Allison R. Demas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia
Angana Mukherjee et al.
MALARIA JOURNAL (2017)
CRISPR Genome-Wide Screening Identifies Dependence on the Proteasome Subunit PSMC6 for Bortezomib Sensitivity in Multiple Myeloma
Chang-Xin Shi et al.
MOLECULAR CANCER THERAPEUTICS (2017)
Characterization of Toxoplasma DegP, a rhoptry serine protease crucial for lethal infection in mice
Gaelle Lentini et al.
PLOS ONE (2017)
Quantification of labile heme in live malaria parasites using a genetically encoded biosensor
James R. Abshire et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220
Panpan Hou et al.
CANCER RESEARCH (2017)
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
Stanley C. Xie et al.
JOURNAL OF CELL SCIENCE (2016)
A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes
Saima M. Sidik et al.
CELL (2016)
The Function of the DegP (HtrA) Protein: Protease Versus Chaperone
Zengyi Chang
IUBMB LIFE (2016)
Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling
Saima M. Sidik et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7
Hanafy M. Ismail et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors
David A. Hanna et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Artemisinin Action and Resistance in Plasmodium falciparum
Leann Tilley et al.
TRENDS IN PARASITOLOGY (2016)
Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients
Andrew Melber et al.
ELIFE (2016)
Stability of the Antimalarial Drug Dihydroartemisinin under Physiologically Relevant Conditions: Implications for Clinical Treatment and Pharmacokinetic and In Vitro Assays
Silvia Parapini et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
Artemisinin Resistance at the China-Myanmar Border and Association with Mutations in the K13 Propeller Gene
Zenglei Wang et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
Kivanc Birsoy et al.
CELL (2015)
Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials
Jill M. Combrinck et al.
MALARIA JOURNAL (2015)
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
Alassane Mbengue et al.
NATURE (2015)
Thermal proteome profiling monitors ligand interactions with cellular membrane proteins
Friedrich B. M. Reinhard et al.
NATURE METHODS (2015)
Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry
Holger Franken et al.
NATURE PROTOCOLS (2015)
MetaboAnalyst 3.0-making metabolomics more meaningful
Jianguo Xia et al.
NUCLEIC ACIDS RESEARCH (2015)
CCTOP: a Consensus Constrained TOPology prediction web server
Laszlo Dobson et al.
NUCLEIC ACIDS RESEARCH (2015)
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
Jigang Wang et al.
NATURE COMMUNICATIONS (2015)
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
Con Dogovski et al.
PLOS BIOLOGY (2015)
Deconvoluting heme biosynthesis to target blood-stage malaria parasites
Paul A. Sigala et al.
ELIFE (2015)
Conditional U1 Gene Silencing in Toxoplasma gondii
Manuela S. Pieperhoff et al.
PLOS ONE (2015)
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
Judith Straimer et al.
SCIENCE (2015)
Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
Sachel Mok et al.
SCIENCE (2015)
The Peculiarities and Paradoxes of Plasmodium Heme Metabolism
Paul A. Sigala et al.
ANNUAL REVIEW OF MICROBIOLOGY, VOL 68 (2014)
A secretory multifunctional serine protease, DegP of Plasmodium falciparum, plays an important role in thermo-oxidative stress, parasite growth and development
Shweta Sharma et al.
FEBS JOURNAL (2014)
The Heme Biosynthesis Pathway Is Essential for Plasmodium falciparum Development in Mosquito Stage but Not in Blood Stages
Hangjun Ke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
TMEM14C is required for erythroid mitochondrial heme metabolism
Yvette Y. Yien et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Frederic Ariey et al.
NATURE (2014)
Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
Mehdi Ghorbal et al.
NATURE BIOTECHNOLOGY (2014)
Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9
Saima M. Sidik et al.
PLOS ONE (2014)
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem et al.
SCIENCE (2014)
Tracking cancer drugs in living cells by thermal profiling of the proteome
Mikhail M. Savitski et al.
SCIENCE (2014)
Toxoplasma gondii Ingests and Digests Host Cytosolic Proteins
Zhicheng Dou et al.
MBIO (2014)
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
Wei Li et al.
GENOME BIOLOGY (2014)
Insights into the Role of Heme in the Mechanism of Action of Antimalarials
Jill M. Combrinck et al.
ACS CHEMICAL BIOLOGY (2013)
Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia
Benoit Witkowski et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation
Marta A. Uzarska et al.
MOLECULAR BIOLOGY OF THE CELL (2013)
Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
Benoit Witkowski et al.
LANCET INFECTIOUS DISEASES (2013)
Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking
Gisela Henriques et al.
MALARIA JOURNAL (2013)
Library of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasites
Achchuthan Shanmugasundram et al.
NUCLEIC ACIDS RESEARCH (2013)
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
Nectarios Klonis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Malaria Parasite-Synthesized Heme Is Essential in the Mosquito and Liver Stages and Complements Host Heme in the Blood Stages of Infection
Viswanathan Arun Nagaraj et al.
PLOS PATHOGENS (2013)
The Use and Abuse of Heme in Apicomplexan Parasites
Giel G. van Dooren et al.
ANTIOXIDANTS & REDOX SIGNALING (2012)
Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii
James I. MacRae et al.
CELL HOST & MICROBE (2012)
Crystal Structure of Arabidopsis Deg2 Protein Reveals an Internal PDZ Ligand Locking the Hexameric Resting State
Renhua Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Mitochondrial ATP synthase: architecture, function and pathology
An I. Jonckheere et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2012)
Monothiol Glutaredoxins Function in Storing and Transporting [Fe2S2] Clusters Assembled on IscU Scaffold Proteins
Priyanka Shakamuri et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Fiji: an open-source platform for biological-image analysis
Johannes Schindelin et al.
NATURE METHODS (2012)
Deg proteases and their role in protein quality control and processing in different subcellular compartments of the plant cell
Holger Schuhmann et al.
PHYSIOLOGIA PLANTARUM (2012)
Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes
Jessie M. Cameron et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins
Aleix Navarro-Sastre et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches
Eric H. Ekland et al.
FASEB JOURNAL (2011)
Plastid-associated Porphobilinogen Synthase from Toxoplasma gondii KINETIC AND STRUCTURAL PROPERTIES VALIDATE THERAPEUTIC POTENTIAL
Dhanasekaran Shanmugam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
Sebastian Lourido et al.
NATURE (2010)
Artemisone and Artemiside Control Acute and Reactivated Toxoplasmosis in a Murine Model
Ildiko R. Dunay et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent
Carmony L. Hartwig et al.
BIOCHEMICAL PHARMACOLOGY (2009)
Tagging of Endogenous Genes in a Toxoplasma gondii Strain Lacking Ku80
My-Hang Huynh et al.
EUKARYOTIC CELL (2009)
Enzymatic assembly of DNA molecules up to several hundred kilobases
Daniel G. Gibson et al.
NATURE METHODS (2009)
Artemisinin Resistance in Plasmodium falciparum Malaria.
Arjen M. Dondorp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Heme Mediates Cytotoxicity from Artemisinin and Serves as a General Anti-Proliferation Target
Shiming Zhang et al.
PLOS ONE (2009)
Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis
Martin Blume et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin
Shiming Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif
Marcus C. S. Lee et al.
MOLECULAR MICROBIOLOGY (2008)
Evidence of Artemisinin-Resistant Malaria in Western Cambodia
Harald Noedl et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
In vitro evaluation of the growth inhibitory activities of 15 drugs against Babesia gibsoni (Aomori strain)
Aya Matsuu et al.
VETERINARY PARASITOLOGY (2008)
ToxoDB: an integrated Toxoplasma gondii database resource
Bindu Gajria et al.
NUCLEIC ACIDS RESEARCH (2008)
Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis
Kisaburo Nagamune et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Control of DegP-dependent degradation of c-type cytochromes by heme and the cytochrome c maturation system in Escherichia coli
Tao Gao et al.
JOURNAL OF BACTERIOLOGY (2007)
Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA
Xin Jie Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii
Paco Pino et al.
PLOS PATHOGENS (2007)
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria
GA Biagini et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans
I Astner et al.
EMBO JOURNAL (2005)
Crystal structure of mitochondrial respiratory membrane protein complex II
F Sun et al.
CELL (2005)
Serine protease mechanism and specificity
L Hedstrom
CHEMICAL REVIEWS (2002)
Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii
JR Radke et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2001)
In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase
MG Reynolds et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)
Mutations in the P-falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
DA Fidock et al.
MOLECULAR CELL (2000)
Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site
M Korsinczky et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)