4.8 Article

Inhibitors of BRAF dimers using an allosteric site

Related references

Note: Only part of the references are listed.
Article Oncology

A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer

Ryan J. Sullivan et al.

MOLECULAR CANCER THERAPEUTICS (2020)

Editorial Material Oncology

Quest for Clinically Effective RAF Dimer Inhibitors

Jenny Y. Xue et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Biotechnology & Applied Microbiology

Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies

Fiona H. Tan et al.

ONCOTARGETS AND THERAPY (2019)

Article Chemistry, Medicinal

Current Insights of BRAF Inhibitors in Cancer

Bogos Agianian et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Polypharmacology-based ceritinib repurposing using integrated functional proteomics

Brent M. Kuenzi et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Ahmet Zehir et al.

NATURE MEDICINE (2017)

Review Oncology

New perspectives for targeting RAF kinase in human cancer

Zoi Karoulia et al.

NATURE REVIEWS CANCER (2017)

Review Biochemistry & Molecular Biology

RAS Proteins and Their Regulators in Human Disease

Dhirendra K. Simanshu et al.

Article Oncology

Absorption, metabolism, and excretion of [14C]ponatinib after a single oral dose in humans

Yihua E. Ye et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2017)

Article Multidisciplinary Sciences

RAF inhibitors that evade paradoxical MAPK pathway activation

Chao Zhang et al.

NATURE (2015)

Article Multidisciplinary Sciences

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Tea Pemovska et al.

NATURE (2015)

Review Cell Biology

Regulation of RAF protein kinases in ERK signalling

Hugo Lavoie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation

Neroshan Thevakumaran et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Chemistry, Medicinal

KLIFS: A Knowledge-Based Structural Database To Navigate Kinase-Ligand Interaction Space

Oscar P. J. van Linden et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Review Biotechnology & Applied Microbiology

Targeting RAS-ERK signalling in cancer: promises and challenges

Ahmed A. Samatar et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Review Oncology

Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond

Matthew Holderfield et al.

NATURE REVIEWS CANCER (2014)

Review Oncology

Resistance to BRAF-targeted therapy in melanoma

Ryan J. Sullivan et al.

EUROPEAN JOURNAL OF CANCER (2013)

Review Biochemistry & Molecular Biology

Tumor adaptation and resistance to RAF inhibitors

Piro Lito et al.

NATURE MEDICINE (2013)

Editorial Material Biology

Collaboration gets the most out of software

Andrew Morin et al.

ELIFE (2013)

Review Biotechnology & Applied Microbiology

Vemurafenib: the first drug approved for BRAF-mutant cancer

Gideon Bollag et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Review Biology

Evolution of the eukaryotic protein kinases as dynamic molecular switches

Susan S. Taylor et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2012)

Article Biochemical Research Methods

iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

T. Geoff G. Battye et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2011)

Article Biochemical Research Methods

Overview of the CCP4 suite and current developments

Martyn D. Winn et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)

Article Multidisciplinary Sciences

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Poulikos I. Poulikakos et al.

NATURE (2011)

Article Biotechnology & Applied Microbiology

Comprehensive analysis of kinase inhibitor selectivity

Mindy I. Davis et al.

NATURE BIOTECHNOLOGY (2011)

Article Biochemistry & Molecular Biology

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

Sonja J. Heidorn et al.

Article Multidisciplinary Sciences

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Poulikos I. Poulikakos et al.

NATURE (2010)

Article Multidisciplinary Sciences

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou et al.

NATURE (2010)

Article Multidisciplinary Sciences

Melanomas acquire resistance toB-RAF(V600E) inhibition by RTK or N-RAS upregulation

Ramin Nazarian et al.

NATURE (2010)

Review Oncology

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Dominico Vigil et al.

NATURE REVIEWS CANCER (2010)

Review Biochemistry & Molecular Biology

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

P. J. Roberts et al.

ONCOGENE (2007)

Article Biochemistry & Molecular Biology

PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results

Steven L. Dixon et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2006)

Review Cell Biology

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

W Kolch

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Review Cell Biology

The RAF proteins take centre stage

C Wellbrock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)