Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41467-020-18590-7
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Funding
- JSPS Core-to-Core Program
- JSPS KAKENHI [JP18K13798, JP20K14785]
- Murata Science Foundation
- University of Tokyo GAP Fund
- National Natural Science Foundation of China [21671020, 61805175]
- Beijing Natural Science Foundation [2172049]
- Nakatani Foundation
- Ogasawara Foundation for the Promotion of Science and Engineering
- MEXT Q-LEAP Program
- White Rock Foundation
- KISTEC
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Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for vibrational spectroscopy as it provides several orders of magnitude higher sensitivity than inherently weak spontaneous Raman scattering by exciting localized surface plasmon resonance (LSPR) on metal substrates. However, SERS can be unreliable for biomedical use since it sacrifices reproducibility, uniformity, biocompatibility, and durability due to its strong dependence on hot spots, large photothermal heat generation, and easy oxidization. Here, we demonstrate the design, fabrication, and use of a metal-free (i.e., LSPR-free), topologically tailored nanostructure composed of porous carbon nanowires in an array as a SERS substrate to overcome all these problems. Specifically, it offers not only high signal enhancement (similar to 10(6)) due to its strong broadband charge-transfer resonance, but also extraordinarily high reproducibility due to the absence of hot spots, high durability due to no oxidization, and high compatibility to biomolecules due to its fluorescence quenching capability.
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