Journal
CURRENT GENETICS
Volume 62, Issue 3, Pages 519-521Publisher
SPRINGER
DOI: 10.1007/s00294-016-0575-5
Keywords
DNA repair; Homologous recombination; Broken chromosomes; DNA replication; RecA; RecBCD; RecF; Double-strand break; Single-strand gap; DNA damage
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Funding
- Agence National de la Recherche [ANR-14-CE09-0010-01]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE09-0010] Funding Source: Agence Nationale de la Recherche (ANR)
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Homologous recombination repairs discontinuities in DNA including single-strand gaps (SSGs) and double-strand breaks (DSBs). This commentary describes how the RecBCD and RecF pathways might be exchangeable for the repair of their respective DSB and SSG canonical substrates. In particular, I will discuss how the RecBCD pathway could engage in the repair of an SSG even when the latter is not associated with a DSB.
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