Journal
REVIEWS IN AQUACULTURE
Volume 13, Issue 1, Pages 431-459Publisher
WILEY
DOI: 10.1111/raq.12482
Keywords
crustaceans; immune response; immunoprotection; shrimp
Categories
Funding
- National Fund for Basic, Strategic and Frontier Application Research in Agriculture (NFBSFARA) [NFBSFARA/BS-3016/2012-13]
- Indian Council of Agricultural Research (ICAR), Government of India
Ask authors/readers for more resources
Crustacean aquaculture, especially shrimp production, is a profitable sector worldwide. Despite lacking a vertebrate-like adaptive immune system, shrimp have an efficient innate immune system consisting of cellular and humoral components. Signal pathways are initiated by pattern recognition receptors, producing effector molecules to combat pathogens.
Crustacean aquaculture, dominated by shrimp, is a highly profitable food-producing sector in the world. However, a variety of biotic and abiotic stressors can have adverse effect on the immune system of shrimp making them susceptible to diseases. Although a vertebrate-like adaptive immune system is lacking in shrimp, an efficient innate immune system renders protection against invading pathogens. The innate immune system comprises two distinct but overlapping components, the cellular and humoral, and these are regulated through several signal transduction pathways. The signal pathways are initiated by the recognition of pathogen-associated molecular patterns by germline-encoded pattern recognition receptors leading to the production of different effector molecules that act against the pathogens. RNAi-mediated post-transcriptional gene silencing and microRNA regulation of immune response have also been found to be functional in shrimp. Similarly, apoptosis and apoptosis-related genes are also reported, besides interferon (IFN) system-like antiviral regulatory mechanism. Further, some form of immune memory, termed 'immune priming' or 'innate immunity with specificity' and 'quasi-immune response' is recorded in shrimp and these abilities have been exploited in verifying the immunoprotection against different pathogens. Antigens developed either directly from the pathogens or through recombinant proteins have been tested for immune-protective ability. RNAi-mediated protection has also been demonstrated against different shrimp viruses. This review summarizes the available scientific information on immune responses and the immunoprotection trials carried out in crustaceans with a focus on shrimp. The available research evidences indicate the potential of developing effective immunoprophylactic measures in shrimp.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available