Journal
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 14, Issue 3, Pages 449-456Publisher
SPRINGER
DOI: 10.1007/s12265-020-10073-w
Keywords
Red cell distribution width; Periprocedural myocardial infarction; Percutaneous coronary intervention
Funding
- National Natural Science Foundation of China [81970295, 81870267, 81670318, 81570314]
- Shanghai Municipal Commission of Health and Family Planning [2017YQ057]
- Shanghai Science and Technology Committee [17411962300]
- National Program on Key Basic Research Project of China (973 Program) [2014CBA02003]
- Program for Outstanding Medical Academic Leader [2015-Weijiwei-24]
- Zhongshan Hospital Affiliated to Fudan University [2015ZSYXGG07, 2017ZSYQ08]
- VG Funding of Clinical Trials [2017-CCA-VG-036]
- Merck Fund [051]
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The study found that high red cell distribution width (RDW) was associated with an increased risk of periprocedural myocardial infarction (PMI) in patients undergoing elective percutaneous coronary intervention (PCI), indicating that RDW is an independent predictor of PMI.
We aimed to investigate whether red cell distribution width (RDW) was associated with periprocedural myocardial infarction (PMI) in patients undergoing elective percutaneous coronary intervention (PCI). Among 1723 consecutive patients undergoing elective PCI, a total of 230 (13.3%) met the diagnostic criteria of PMI. The high RDW (>= 12.6%) group tended to have PMI (15.4% vs. 11.2%,P = 0.010). RDW was an independent predictor of PMI whether as a categorical variable (adjusted odds ratio = 1.442, 95% confidence interval = 1.088 to 1.911,P = 0.011) or a continuous variable (adjusted odds ratio = 1.236, 95% confidence interval = 1.079 to 1.415,P = 0.002). High RDW was also significantly associated with increased risk of major adverse cardiovascular events (MACE) during follow-up. However, anemia was not independently associated with PMI or MACE in the current study. In conclusion, RDW showed strong and independent association with PMI in patients undergoing elective PCI.
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