Journal
CURRENT DRUG TARGETS
Volume 17, Issue 8, Pages 942-953Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450116666150416120559
Keywords
AMPK-activated protein kinase; bacteria; energy metabolism; infectious diseases; parasites; pathogens; pharmacological drugs; therapeutics; virus
Categories
Funding
- INSERM, CNRS
- Universite Paris Descartes
- Canada Research Chair program
- European Community [602773]
- FCT-Foundation for Science and Technology [IF/00021/2014]
- [SFRH/BD/91543/2012]
Ask authors/readers for more resources
Intracellular pathogens are known to manipulate host cell regulatory pathways to establish an optimal environment for their growth and survival. Pathogens employ active mechanisms to hijack host cell metabolism and acquire existing nutrient and energy store. The role of the cellular energy sensor AMP-activated protein kinase (AMPK) in the regulation of cellular energy homeostasis is well documented. Here, we highlight recent advances showing the importance of AMPK signaling in pathogen-host interactions. Pathogens interact with AMPK by a variety of mechanisms aimed at reprogramming host cell metabolism to their own benefit. Stimulation of AMPK activity provides an efficient process to rapidly adapt pathogen metabolism to the major nutritional changes often encountered during the different phases of infection. However, inhibition of AMPK is also used by pathogens to manipulate innate host response, indicating that AMPK appears relevant to restriction of pathogen infection. We also document the effects of pharmacological AMPK modulators on pathogen proliferation and survival. This review illustrates intricate pathogen-AMPK interactions that may be exploited to the development of novel anti-pathogen therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available