Alteration of Resting-state Functional Connectivity in the Sensorimotor Network in Patients with Thalamic Infarction

Purpose To explore changes in functional connectivity (FC) within the sensorimotor network (SMN) and the relationship between the SMN and bilateral thalamus in patients with thalamic infarction (TI) using resting state functional magnetic resonance imaging (rs-fMRI). Also determined was whether those measures are useful for monitoring the functional recovery of somatosensory deficits. Methods The study included 31 patients with TI presenting somatosensory dysfunction and 31 controls who underwent clinical assessments and MRI scanning at 6 months after a stroke. An independent component analysis was used to identify the SMN. The mean time courses of SMN activity were extracted for each subject, and FC with the bilateral thalamus was assessed. Differences in connectivity strength were compared between groups. Finally, we correlated the altered FC values with clinical data from patients with TI. Results Compared to controls, patients with TI showed decreases in FC within SMN in the ipsilesional posterior central gyrus (PCG) (Z-score= -4.581, cluster size= 171), but presented increased FC within the SMN in the ipsilesional supplementary motor area (SMA) (Z-score= 4.648, cluster size= 46). The FC values of the ipsilesional SMA correlated with the somatosensory function score of patients with TI (r= 0.426, P= 0.027). Increased FC was observed between the SMN and bilateral thalamus in patients with TI. The region exhibiting increased FC was adjacent to the lesion in the affected thalamus, while the area with increased FC overlapped the location of the lesion when the lesion was mirrored onto the unaffected thalamus. Conclusion The increased FC in the ipsilesional SMA and between the SMN and perilesional thalamus might reflect functional reorganization in patients with TI presenting somatosensory deficits.

Automated summary

The study aimed to analyze changes in functional connectivity within the sensorimotor network (SMN) and the relationship between SMN and bilateral thalamus in patients with thalamic infarction (TI) using rs-fMRI. Patients with TI showed decreased FC within SMN in the ipsilesional posterior central gyrus (PCG) but increased FC in the ipsilesional supplementary motor area (SMA) compared to controls. The increased FC in the ipsilesional SMA and between SMN and perilesional thalamus in patients with TI may indicate functional reorganization in patients with somatosensory deficits.