Journal
VIRUSES-BASEL
Volume 12, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/v12101090
Keywords
Flaviviridae; flavivirus; hepacivirus; HCV; pestivirus; signal peptidase; delayed processing; nucleocapsid; virus assembly
Categories
Funding
- National Institute of Allergy and Infectious Diseases [R01AI110358-01A1, R01AI146277-01A1]
- King Saud bin Abdulaziz University for Health Sciences
Ask authors/readers for more resources
The Flaviviridae virus family is classified into four different genera, including flavivirus, hepacivirus, pegivirus, and pestivirus, which cause significant morbidity and mortality in humans and other mammals, including ruminants and pigs. These are enveloped, single-stranded RNA viruses sharing a similar genome organization and replication scheme with certain unique features that differentiate them. All viruses in this family express a single polyprotein that encodes structural and nonstructural proteins at the N- and C-terminal regions, respectively. In general, the host signal peptidase cleaves the structural protein junction sites, while virus-encoded proteases process the nonstructural polyprotein region. It is known that signal peptidase processing is a rapid, co-translational event. Interestingly, certain signal peptidase processing site(s) in different Flaviviridae viral structural protein precursors display suboptimal cleavage kinetics. This review focuses on the recent progress regarding the Flaviviridae virus genus-specific mechanisms to downregulate signal peptidase-mediated processing at particular viral polyprotein junction sites and the role of delayed processing at these sites in infectious virus particle assembly.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available