Journal
CURRENT DIABETES REPORTS
Volume 16, Issue 3, Pages -Publisher
CURRENT MEDICINE GROUP
DOI: 10.1007/s11892-016-0724-8
Keywords
Diabetic nephropathy; MicroRNA; Biomarker; Therapeutics; Fibrosis; Non-coding RNA
Categories
Funding
- Health and Care Research Wales
- Kidney Research UK [RP44/2014]
- National Institute for Health Research (NIHR) Invention for Innovation (i4i) Programme [II-LA-0712-20003]
- Kidney Research UK [RP44/2014] Funding Source: researchfish
- National Institute for Health Research [II-LA-0712-20003] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [II-LA-0712-20003] Funding Source: National Institutes of Health Research (NIHR)
Ask authors/readers for more resources
Recent estimates suggest that 1 in 12 of the global population suffers from diabetes mellitus. Approximately 40 % of those affected will go on to develop diabetes-related chronic kidney disease or diabetic nephropathy (DN). DN is a major cause of disability and premature death. Existing tests for prognostic purposes are limited and can be invasive, and interventions to delay progression are challenging. MicroRNAs (miRNAs) are a recently described class of molecular regulators found ubiquitously in human tissues and bodily fluids, where they are highly stable. Alterations in miRNA expression profiles have been observed in numerous diseases. Blood and tissue miRNAs are already established cancer biomarkers, and cardiovascular, metabolic and immune disease miRNA biomarkers are under development. Urinary miRNAs represent a potential novel source of non-invasive biomarkers for kidney diseases, including DN. In addition, recent data suggest that miRNAs may have therapeutic applications. Here, we review the utility of miRNAs as biomarkers for the early detection and progression of DN, assess emerging data on miRNAs implicated in DN pathology and discuss how the data from both fields may contribute to the development of novel therapeutic agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available