Journal
CURRENT CANCER DRUG TARGETS
Volume 16, Issue 6, Pages 509-521Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009616666151130213910
Keywords
Bleomycin; electrochemotherapy; liposomes; microsphere; nanoparticles; photochemical internalization; targeted drug delivery; ultrasound
Categories
Funding
- Natural Science Foundation of China (NSFC) Project [81541086, 51403042, 31370781, 21372183]
- Natural Science Foundation of Guangdong Province [2014A030310310]
- Hubei Province Natural Science Foundation [2013CFB328]
- Applied Basic Research Programs of Wuhan, China [2015060101010069]
- Key Laboratory of Analytical Chemistry for Biology and Medicine (Wuhan University), Ministry of Education [ACBM2014001]
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
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Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.
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