Journal
CURRENT CANCER DRUG TARGETS
Volume 16, Issue 4, Pages 346-356Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568009616666151207105851
Keywords
Cancer treatment; Chinese medicine; drug resistance; effect; immunity; side effects; synergistic combination
Categories
Funding
- Key Program of National Natural Science Foundation of China [81330084]
- E-institutes of Shanghai Municipal Education Commission [E 03008]
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The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms of enhancing efficacy, reducing side effects, immune modulation, as well as abrogating drug resistance. Our conclusions support the development of further science-based holistic modalities for cancer care.
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