Journal
VIRUS RESEARCH
Volume 286, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2020.198043
Keywords
SARS-Coronavirus-2; 2019 Coronavirus disease; Cluster-onset families; Solitary-onset families
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An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a clustering epidemic pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs.
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