Journal
VACCINE
Volume 38, Issue 45, Pages 7094-7099Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2020.08.074
Keywords
Salmonella enterica serovar Enteritidis (S. Enteritidis); Subunit vaccine; Outer membrane vesicles (OMVs); OmpF; OmpC
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Funding
- National Key Research and Development Program of China [2017YFD0500705]
- National Natural Science Foundation of China [3192010301, 31730094]
- Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)
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Salmonella enterica serovar Enteritidis remains the most prevalent serotype causing human salmonellosis through the consumption of contaminated foods, especially poultry products. The development of a subunit vaccine against S. Enteritidis can not only protect chickens against Salmonella infection in the poultry industry but also cut the transmission sources. In this study, both the expressed recombinant outer membrane protein F (rOmpF) and extracted outer membrane vesicles (OMVs) were developed as subunit vaccines against S. Enteritidis challenge in chickens. Immunization with the subunit vaccine could induce not only antibody production but also strong cell-mediated immune response. Both rOmpF plus QuilA adjuvant and OMVs alone had highly protective efficacy against S. Enteritidis challenge and rapidly decreased the colonization of bacteria in chicken. These findings revealed the potential application of rOmpF and OMVs as subunit vaccines in the poultry industry. (C) 2020 Elsevier Ltd. All rights reserved.
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