Journal
VACCINE
Volume 38, Issue 44, Pages 6914-6921Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2020.08.058
Keywords
Immunization; Diphtheria toxoid; Tetanus toxoid; Hemophilus influenzae; Pregnancy; Infant
Categories
Funding
- GlaxoSmithKline Biologicals
- Thrasher Research Fund [EWAT 12348]
- Ratchadaphiseksomphot Endowment Fund, Faculty of Medicine, Chulalongkorn University [CU_GR(S)_61_36_30_01]
- Center of Excellence in Clinical Virology, Chulalongkorn University, King Chulalongkorn Memorial Hospital
- National Science and Technology Development Agency [P-15-5004]
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Introduction: Vaccination of pregnant women protects both women and their newborns against some infectious diseases. Thailand implemented tetanus toxoid (TT) vaccination of pregnant women in 1977, which was replaced by tetanus-diphtheria toxoid (dT) vaccination in 2005. The tetanus-diphtheria-acel lular pertussis (Tdap) vaccine has been recommended for pregnant women at 27-36 weeks of gestation since 2012 in several countries. Data on antibody responses to diphtheria toxoid (DT), TT, and Hemophilus influenzae type b (Hib) induced by combined vaccines in children born to TT-vaccinated and/or Tdapvaccinated mothers are limited. Material and methods: We investigated anti-DT, anti-TT, and anti-Hib IgG responses in a cohort of Thai children (ClinicalTrial.gov NCT02408926) born to mothers who received a TT-containing and/or the Tdap vaccine during pregnancy. Children born to Tdap-vaccinated mothers were randomized to receive either a hexavalent (Infanrix-hexa) or pentavalent (Quinvaxem) vaccine, whereas children born to TT-vaccinated mothers received only Quinvaxem vaccine at 2, 4, 6, and 18 months of age. IgG levels were evaluated at birth (cord blood), 2 (pre-primary), 7 (post-primary), 18 (pre-booster), and 19 months of age (post-booster) using a commercially available enzyme-linked immunoassay. Results: Seroprotective concentrations of anti-DT, anti-TT, and anti-Hib IgG were achieved in >90% and >99% of children following primary and booster vaccination, respectively. Among children born to Tdap-vaccinated mothers, the pentavalent vaccine induced higher levels of anti-Hib IgG than the hexavalent vaccine after primary and booster vaccination. Significantly higher anti-Hib IgG levels were observed among children receiving the pentavalent vaccine and who were born to TT-vaccinated mothers than among children receiving the pentavalent vaccine and born to Tdap-vaccinated mothers after primary and booster vaccination. Conclusions: Vaccination with a TT-containing and/or the Tdap vaccine during pregnancy did not compromise the seroprotection rate achieved following primary and booster immunization in individuals receiving either the pentavalent or hexavalent vaccine. (c) 2020 Elsevier Ltd. All rights reserved.
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