4.8 Editorial Material

Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose

Journal

CURRENT BIOLOGY
Volume 26, Issue 5, Pages R207-R209

Publisher

CELL PRESS
DOI: 10.1016/j.cub.2016.01.009

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Drp1 is an oligomeric GTPase essential for mitochondrial division. A recent study has proposed a new model whereby machinery localized to the endoplasmic reticulum drives polymerization of actin, which then acts as a platform for Drp1 oligomerization and hydrolysis at mitochondrial constriction sites.

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