Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 41, Issue 10, Pages 686-689Publisher
CELL PRESS
DOI: 10.1016/j.tips.2020.07.005
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Oral administration of drugs is one of the most patient-friendly drug delivery routes. However, drug bioavailability via the oral route remains poor due to the harsh gastrointestinal environment. In recent years, many nanocarriers have been designed to overcome this limitation. Among those, chitosan nanoparticles (ChNPs) have proved to be a quite popular choice. Here, we highlight the use of fluorescein isothiocyanate-tagged ChNPs as an invaluable tool to monitor the fate of ChNPs encapsulating oral drugs, leading to an in-depth understanding of drug biodistribution and, in turn, shedding light on ways to improve bioavailability.
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