Journal
TRENDS IN PARASITOLOGY
Volume 36, Issue 12, Pages 959-969Publisher
CELL PRESS
DOI: 10.1016/j.pt.2020.08.005
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Funding
- Biotechnology and Biological Sciences Research Council (BBSRC) [London Interdisciplinary Doctoral Training Programme] [BB/M009513/1]
- London International Development Centre (LIDC), (pump-priming grant)
- BBSRC [2089230] Funding Source: UKRI
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Traditionally, the protozoan parasite Toxoplasma gondii has been thought of as relevant to public health primarily within the context of congenital toxoplasmosis or postnatally acquired disease in immunocompromised patients. However, latent T. gondii infection has been increasingly associated with a wide variety of neuropsychiatric disorders and, more recently, causal frameworks for these epidemiological associations have been proposed. We present assimilated evidence on the associations between T. gondii and various human neuropsychiatric disorders and outline how these may be explained within a unifying causal framework. We argue that the occult effects of latent T. gondii infection likely outweigh the recognised overt morbidity caused by toxoplasmosis, substantially raising the public health importance of this parasite.
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