Journal
TRENDS IN MICROBIOLOGY
Volume 29, Issue 4, Pages 309-319Publisher
CELL PRESS
DOI: 10.1016/j.tim.2020.07.002
Keywords
-
Categories
Funding
- Boehringer Ingelheim Foundation
- Deutsche Forschungsgemeinschaft [398066876/GRK 2485/1]
- German Federal Ministry of Health [ZMVI1-2518FSB705]
- German Federal Ministry of Education and Research [16GW0202]
Ask authors/readers for more resources
HEV is a long-neglected RNA virus and the major causative agent of acute viral hepatitis worldwide. Understanding the interactions between HEV and host cells can provide important insights for studying the viral life cycle and help in designing new therapeutic strategies.
The molecular interplay between cellular host factors and viral proteins is a continuous process throughout the viral life cycle determining virus host range and pathogenesis. The hepatitis E virus (HEV) is a long-neglected RNA virus and the major causative agent of acute viral hepatitis in humans worldwide. However, the mechanisms of liver pathology and clinical disease remain poorly understood for HEV infection. This review summarizes our current understanding of HEV? host cell interactions and highlights experimental strategies and techniques to identify novel host components required for the viral life cycle as well as restriction factors. Understanding these interactions will provide insight into the viral life cycle of HEV and might further help to devise novel therapeutic strategies and antiviral targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available