Journal
TRENDS IN GENETICS
Volume 37, Issue 1, Pages 86-97Publisher
CELL PRESS
DOI: 10.1016/j.tig.2020.09.014
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RNA binding proteins (RBPs) play crucial roles in a variety of regulatory events, ranging from direct gene expression regulation to guiding RNA modification. Over the past decade, the development of high-throughput methods has been instrumental in uncovering new functions of RBPs and elucidating the underlying molecular mechanisms of regulatory events.
RNA binding proteins (RBPs) are ubiquitously found in all kingdoms of life. They are involved in a plethora of regulatory events, ranging from direct regulation of gene expression to guiding modification of RNA molecules. As bacterial regulators, RBPs can act alone or in concert with RNA-based regulators, such as small regulatory RNAs (sRNAs), riboswitches, or clustered regularly interspaced short palindromic repeats (CRISPR) RNAs. Various functions of RBPs, whether dependent or not on an RNA regulator, have been described in the past. However, the past decade has been a fertile ground for the development of novel high-throughput methods. These methods acted as stepping-stones for the discovery of new functions of RBPs and helped in the understanding of the molecular mechanisms behind previously described regulatory events. Here, we present an overview of the recently identified roles of major bacterial RBPs from different model organisms. Moreover, the tight relationship between RBPs and RNA-based regulators will be explored.
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