4.6 Editorial Material

Base Editing Landscape Extends to Perform Transversion Mutation

Journal

TRENDS IN GENETICS
Volume 36, Issue 12, Pages 899-901

Publisher

CELL PRESS
DOI: 10.1016/j.tig.2020.09.001

Keywords

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Funding

  1. ICAR, New Delhi
  2. Department of Biotechnology, Government of India -RA program
  3. National Science Foundation, Plant Genome Research Program grants [IOS-1758745, IOS-2029889]
  4. US Department of Agriculture, Biotechnology Risk Assessment Grant Program competitive grants [2018-33522-28789, 2020-33522-32274]
  5. Foundation for Food and Agriculture Research grant [593603]
  6. Syngenta
  7. NRRI

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Base editors have drawn considerable academic and industrial attention in recent years because of their ability to alter single DNA bases with precision. However, the existing cytosine and adenine base editors can only install transition mutations. Three recent studies (Kurt et al., Zhao et al., and Chen et al.) expand the base editing toolbox by developing cytosine transversion base editors.

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