Journal
TRENDS IN GENETICS
Volume 37, Issue 2, Pages 143-159Publisher
CELL PRESS
DOI: 10.1016/j.tig.2020.08.010
Keywords
-
Categories
Funding
- National Institutes of Health [R01GM120209]
- Ohio State University Center for RNA Biology
- Pelotonia program
Ask authors/readers for more resources
Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control mechanism in all eukaryotes, especially crucial in vertebrates. In vertebrates, NMD is a complex, branched pathway that regulates specific mRNA subsets to fulfill distinct physiological functions.
Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control mechanism in all eukaryotes that regulates the expression of a significant fraction of both the aberrant and normal transcriptomes. In vertebrates, NMD has become an essential process owing to expansion of the diversity of NMD-regulated transcripts, particularly during various developmental processes. Surprisingly, however, some core NMD factors that are essential for NMD in simpler organisms appear to be dispensable for vertebrate NMD. At the same time, numerous NMD enhancers and suppressors have been identified in multicellular organisms including vertebrates. Collectively, the available data suggest that vertebrate NMD is a complex, branched pathway wherein individual branches regulate specific mRNA subsets to fulfill distinct physiological functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available