Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 31, Issue 12, Pages 918-927Publisher
CELL PRESS
DOI: 10.1016/j.tem.2020.09.003
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Funding
- Fondazione Italiana Ricerca sulle Malattie dell'Osso (F.I.R.M.O.)
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The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sexspecific management the disease.
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