Journal
TRENDS IN CELL BIOLOGY
Volume 30, Issue 12, Pages 990-1013Publisher
CELL PRESS
DOI: 10.1016/j.tcb.2020.09.009
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Funding
- European Research Council (ERC) [725229, 851936]
- Dutch Heart Foundation [2019T049]
- European Research Council (ERC) [851936] Funding Source: European Research Council (ERC)
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The administration of (stem) cell-derived extracellular vesicles (EVs) promotes tissue repair through management of different inflammatory, proliferative and remodeling processes in the body. Despite the widely observed biological and therapeutic roles of EVs in wound healing and tissue repair, knowledge on how EVs activate recipient cells and which EV cargo is responsible for the subsequent functional effects is limited. Recent studies hint toward an important role for proteins as functional EV cargo. Here, we provide an overview of how EV-associated proteins promote tissue repair processes and discuss current challenges in evaluating their contribution to EV function and future directions for translating fundamental insights into clinically relevant EV therapies.
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