Journal
TRENDS IN CELL BIOLOGY
Volume 30, Issue 12, Pages 951-966Publisher
CELL PRESS
DOI: 10.1016/j.tcb.2020.08.007
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Funding
- European Commission [FP7 GA ERC-2012-SyG_318987-ToPAG]
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through Germany's Excellence Strategy [EXC 2067/1- 390729940]
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Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are still lacking. Therefore, therapeutic strategies are limited to symptomatic treatments. A common histopathological hallmark of many neurodegenerative diseases is the presence of large pathognomonic protein aggregates, but their role in the disease pathology is unclear and subject to controversy. Here, we discuss imaging methods allowing investigation of these structures within their cellular environment: conventional electron microscopy (EM), super-resolution light microscopy (SR-LM), and cryo-electron tomography (cryo-ET). Multidisciplinary approaches are key for understanding neurodegenerative diseases and may contribute to the development of effective treatments. For simplicity, we focus on huntingtin aggregates, characteristic of Huntington's disease.
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