Journal
TRENDS IN BIOTECHNOLOGY
Volume 39, Issue 5, Pages 445-459Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2020.08.002
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Funding
- Federal Ministry of Education and Research of Germany (BMBF) [13XP5073A -PolyAntiBak]
- MaxSynBio Consortium - BMBF
- MaxSynBio Consortium - Max Planck Society
- German Research Foundation [SFB 1129]
- Volkswagenstiftung
- Alexander von Humboldt foundation
- Heidelberg Biosciences International Graduate School
- Max Planck School Matter to Life
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This article discusses the use of novel modular manufacturing approaches, combined with bottom-up synthetic biology principles and microfluidics, to construct programmable drug carriers in order to overcome some fundamental limitations of nanomedicine.
Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which relies on the use of nanotechnologies to fight disease, was envisaged to fulfill this coveted goal. Despite substantial progress, the structural complexity of therapeutic vehicles impedes their broad clinical application. Novel modular manufacturing approaches for engineering programmable drug carriers may be able to overcome some fundamental limitations of nanomedicine. We discuss how bottom-up synthetic biology principles, empowered by microfluidics, can palliate current drug carrier assembly limitations, and we demonstrate how such a magic bullet could be engineered from the bottom up to ultimately improve clinical outcomes for patients.
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