Journal
TRENDS IN BIOTECHNOLOGY
Volume 39, Issue 3, Pages 286-297Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2020.08.004
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Funding
- National Key Research and Development Program of China [2019YFA0906400]
- National First-Class Discipline Program of Light Industry Technology and Engineering [LITE2018-08]
- National Natural Science Foundation of China [31900067]
- Fundamental Research Funds for the Central Universities [JUSRP52021A, JUSRP11912]
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Biosynthesis of hemoglobin has become an attractive alternative to chemical extraction, with various microorganisms having synthesized several hemoglobins through metabolic engineering and synthetic biology. These novel strategies not only meet increasing demands but also serve as references for producing other heme-binding proteins.
Hemoglobin is a cofactor-containing protein with heme that plays important roles in transporting and storing oxygen. Hemoglobins have been widely applied as acellular oxygen carriers, bioavailable iron-supplying agents, and food-grade coloring and flavoring agents. To meet increasing demands and overcome the drawbacks of chemical extraction, the biosynthesis of hemoglobin has become an attractive alternative. Several hemoglobins have recently been synthesized by various microorganisms through metabolic engineering and synthetic biology. In this review, we summarize the novel strategies that have been used to biosynthesize hemoglobin. These strategies can also serve as references for producing other heme-binding proteins.
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