Journal
TRENDS IN BIOTECHNOLOGY
Volume 39, Issue 6, Pages 560-573Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2020.09.007
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Funding
- Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM)
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/M017702/1]
- BBSRC CASE studentship [BB/R505912/1]
- Engineering and Physical Sciences Research Council (EPSRC) [BB/M017702/1]
- BBSRC [1924609, BB/M017702/1] Funding Source: UKRI
- EPSRC [EP/S01778X/1] Funding Source: UKRI
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Spider silk is known for its impressive mechanical properties, but farming spiders for silk is impractical. Research focuses on producing recombinant spider silk proteins in more feasible hosts, with the goal of developing a highly efficient and cost-effective production system. Genes encoding these proteins have been successfully expressed in various host platforms, showing potential for large-scale production.
Spider silk is renowned for its impressive mechanical properties. It is one of the strongest known biomaterials, possessing mechanical properties that outmatch both steel and Kevlar. However, the farming of spiders for their silk is unfeasible. Consequently, production of recombinant spider silk proteins (spidroins) in more amenable hosts is an exciting field of research. For large-scale production to be viable, a heterologous silk production system that is both highly efficient and cost effective is essential. Genes encoding recombinant spidroin have been expressed in bacterial, yeast, insect, and mammalian cells, in addition to many other platforms. This review discusses the recent advances in exploiting an increasingly diverse range of host platforms in the heterologous production of recombinant spidroins.
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