Journal
CURRENT BIOLOGY
Volume 26, Issue 16, Pages R772-R775Publisher
CELL PRESS
DOI: 10.1016/j.cub.2016.06.066
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Growing evidence highlights the crucial physiological functions of microglia that rely on their phagocytic activities, which can be compromised with age. A new study reports the impaired clearance of myelin debris by microglia in the brain, leading to insoluble lysosomal inclusions and contributing to the immune dysfunction and senescence of these cells.
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