p-TSA-catalyzed a simple and efficient one-pot eco-friendly synthesis of functionalized new isoxazolyl-4-hydroxyindole-3-carboxylate derivatives in aqueous medium

A simple, efficient, cost-effective and one-pot eco-friendly protocol has been developed for the synthesis of new isoxazolyl-4-hydroxyindole-3-carboxylate derivatives by using 4-amino-3-methyl-5-styrylisoxazoles, 2,3-diketoesters and 1,3-cyclohexanediones, in the presence ofp-toluenesulfonic acid (p-TSA) catalyst in aqueous medium. The advantages of this protocol are inexpensive catalyst, metal-free, shorter reaction time, environmentally friendly, high yields, water as a solvent, wide substrates scope and easy purification.

Automated summary

An eco-friendly method using water as a solvent has been developed for the simple and efficient synthesis of new isoxazolyl-4-hydroxyindole-3-carboxylate derivatives, featuring advantages such as cost-effectiveness and metal-free chemistry.