Journal
SYNTHESIS-STUTTGART
Volume 53, Issue 1, Pages 79-94Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1707272
Keywords
iron; diazo compounds; carbenes; insertion; olefination; green chemistry
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-201704272]
- Fonds Quebecois de la Recherche sur la Nature et les Technologies (FQRNT) (Centre in Green Chemistry and Catalysis) Strategic Cluster [FRQNT-2020-RS4-265155-CCVC]
- Universite Laval
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The use of iron catalysis in reactions involving diazo compounds has become increasingly popular, offering a valuable alternative to toxic and expensive metal catalysts. Iron-mediated reactions have shown great potential in forging carbon-carbon or carbon-heteroatom bonds through insertion reactions, ylide formation, and other methods.
The use of iron catalysis to enable reactions with diazo compounds has emerged as a valuable tool to forge carbon-carbon or carbon-heteroatom bonds. While diazo compounds are often encountered with toxic and expensive metal catalysts, such as Rh, Ru, Pd, Ir, and Cu, a resurgence of Fe catalysis has been observed. This short review will showcase and highlight the recent advances in iron-mediated reactions of diazo compounds. 1 Introduction 2 Insertion Reactions 2.1 Insertion into B-H Bonds 2.2 Insertion into Si-H Bonds 2.3 Insertion into N-H Bonds 2.4 Insertion into S-H bonds 3 Ylide Formation and Subsequent Reactions 3.1 Doyle-Kirmse Rearrangement 3.2 [1,2]-Stevens and Sommelet-Hauser Rearrangements 3.3 Olefination Reactions 3.4 Cycloaddition Reactions 3.5 gem-Difluoroalkenylation 4 Three-Component Reactions 5 Miscellaneous 6 Conclusion
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