Concise Diastereoselective Total Synthesis of (+/-)-Parvistemonine A

We have developed a concise diastereoselective total synthesis of (+/-)-parvistemonine A. By using a Mukaiyama-Michael addition, an aza-Wittig reaction, a Paal-Knorr pyrrole synthesis, an acid-mediated annulation, and a Mitsunobu reaction as key steps, we achieved a total synthesis in which the longest linear sequence was ten steps and the overall yield was 19.6%. Additionally, the relative stereochemistry of parvistemonine A was confirmed by X-ray crystallographic analysis for the first time.