Journal
SYNLETT
Volume 32, Issue 4, Pages 373-377Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1707252
Keywords
photocatalysis; palladium catalysis; C-H activation; acylation; iminyl radical; oxime esters
Categories
Funding
- NNSFC [21971081, 91856119]
- Science and Technology Department of Hubei Province [2017AHB047]
- Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]
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An unprecedented dual photoredox/palladium-catalyzed reaction using oxime esters for C-C bond cleavage and directed ortho C-H acylation of 2-arylpyridines has been described. This redox-neutral protocol demonstrates excellent regioselectivity, broad substrate scope, and good functional-group tolerance, resulting in a range of aryl ketones with generally good yields.
An unprecedented dual photoredox/palladium-catalyzed iminyl-radical-mediated C-C bond cleavage and directed ortho C-H acylation of 2-arylpyridines by using oxime esters is described. Oxime esters can serve as efficient acyl sources through formation of the corresponding acyl radicals by photoredox-catalyzed iminyl-radical-mediated C-C bond cleavage. This redox-neutral protocol features excellent regioselectivity, a broad substrate scope, and good functional-group tolerance with respect to both components, giving a broad range of aryl ketones with generally good yields.
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