Journal
SYNLETT
Volume 32, Issue 1, Pages 86-90Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1707321
Keywords
triazoles; tosylhydrazones; cycloaddition; potassium butoxide
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Funding
- Natural Science Foundation of Hainan Province [219MS044]
- National Natural Science Foundation of China [NSFC-21562019]
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In this study, intermolecular cycloaddition of tosylhydrazones with nitriles was investigated. t-BuOK was found to be an excellent base for increasing reaction effectiveness, while using xylene as a solvent significantly inhibited homocoupling of the tosylhydrazones. As a result, a variety of 4,5-diaryl-2H-1,2,3-triazoles were prepared in good to excellent yields and high purities, with the process being azide-free and transition-metal-free.
Intermolecular cycloaddition of tosylhydrazones with nitriles was investigated.t-BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol, and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2H-1,2,3-triazoles were prepared in good to excellent yields and with high purities. The process is azide-free and transition-metal-free.
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