4.4 Article

Transition-Metal-Catalyzed Intermolecular C-H Carbonylation toward Amides

Journal

SYNLETT
Volume 32, Issue 1, Pages 7-13

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1706416

Keywords

C-H functionalization; amidation; carbon monoxide; azides; isocyanates; amide

Funding

  1. NNSFC [21772208]
  2. NSFC of Jiangsu Province [BK20161260]
  3. Key Research Program of Frontier Sciences of CAS [QYZDJSSW-SLH051]
  4. Joint Open Fund of Jiangsu Collaborative Innovation Center for Ecological Building Materials and Environmental Protection Equipment and Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province [JH201863]

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The amide linkage is a crucial structural moiety in chemistry and biology. Recent advances in catalytic intermolecular C-H carbonylation reactions, particularly the intermolecular C-H amidation of arenes with carbon monoxide and organic azides for amide synthesis, are discussed.
The amide linkage is one of the most important structural moieties in both chemistry and biology. Here, we briefly discuss recent advances in catalytic intermolecular C-H carbonylation reactions for the synthesis of amides, with particular attention to our intermolecular C-H amidation of arenes with carbon monoxide and organic azides to produce amides.

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